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Reversible alopecia in Vogt-Koyanagi-Harada disease and sympathetic ophthalmia

Chiu-Tung Chuang1, Po-Sian Huang1, Shih-Chou Chen1 and Shwu-Jiuan Sheu12*

Author Affiliations

1 Department of Ophthalmology, Kaohsiung Veterans General Hospital, 386, Ta-Chung 1st Road, Kaohsiung, 813, Taiwan

2 School of Medicine, National Yang-Ming University, Taipei, 112, Taiwan

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Journal of Ophthalmic Inflammation and Infection 2013, 3:41  doi:10.1186/1869-5760-3-41

Published: 15 March 2013

Abstract

Background

Vogt-Koyanagi-Harada (VKH) disease and sympathetic ophthalmia (SO) are both autoimmune disorders targeting melanin-bearing cells, even though their etiologies are different. Both shared many ocular and systemic manifestations, including integumentary findings. Most of the literature focused on the ocular manifestations and related treatment. Alopecia was seldom mentioned.

Findings

We report one case of VKH disease and one case of SO. Both developed severe alopecia and early sunset glow fundus, which are probably due to incomplete treatment. Fortunately, the alopecia improved soon after systemic steroid treatment.

Conclusions

Early and complete treatments are important in the management of VKH or SO and prevent integumentary manifestation. Alopecia can be reversible after steroid treatment in time.