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Spontaneous closure of macular holes secondary to posterior uveitis: case series and a literature review

Nicolas Bonnin1*, Pierre-Loïc Cornut2, Florian Chaise2, Elodie Labeille2, Helene Janin Manificat2, Audrey Feldman2, Laurent Perard3, Franck Bacin1, Frédéric Chiambaretta1 and Carole Burillon2

Author Affiliations

1 Service d'Ophtalmologie, Pôle Médecine Interne-Ophtalmologie-ORL, CHU Clermont-Ferrand, Clermont-Ferrand, 63003, France

2 Department of Ophthalmology, Hospices Civils de Lyon, University Hospital, Claude Bernard Lyon I University, Lyon, 69008, France

3 Department of Internal Medicine, Edouard-Herriot Hospital, place d'Arsonval, Lyon, 69008, France

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Journal of Ophthalmic Inflammation and Infection 2013, 3:34  doi:10.1186/1869-5760-3-34

Published: 11 February 2013


The occurrence of a macular hole due to posterior uveitis is infrequently reported. We report the evolution of three cases of macular holes secondary to posterior segment inflammation. A complete inflammatory and infectious assessment found one case of toxocariasis, one of sarcoidosis, and one of syphilis. After medical etiological treatment, macular hole closure was rapidly obtained in all the cases and confirmed by spectral domain optic coherence tomography, with visual acuity improvement. Fibrous scarring developed in two cases, and foveal photoreceptor complex normalization was observed in the sarcoidosis case. These observations demonstrate that macular holes secondary to posterior uveitis frequently resolve without surgical intervention and so could be underdiagnosed if the patient is not evaluated at the time of onset before spontaneous hole closure.

Posterior uveitis; Macular hole; Toxocara canis; Sarcoidosis; Syphilis